Prävention psychischer Erkrankungen

Altscherbitz
Sächsisches Krankenhaus für Psychiatrie und Neurologie Altscherbitz: Früherkennungszentrum für Psychosen

Berlin
Alexianer St. Joseph Berlin-Weißensee GmbH: Früherkennungs- und Therapiezentrum für beginnende Psychosen (FeTZ)

Bonn
Universitätsklinikum Bonn: Bonner Früherkennungszentrum für Psychosen

Düsseldorf
Landschaftsverband Rheinland - Klinikum Düsseldorf: Früherkennung und -behandlung psychotischer Erkrankungen

Freiburg
Universitätsklinikum Freiburg: Spezialsprechstunde zur Früherkennung psychotischer Erkrankungen

Hamburg
Asklepios Klinik Nord - Ochsenzoll: Station O 54A - Erstmanifestation psychotischer Störungen

Herten
Landschaftsverband Westfalen-Lippe - Klinik Herten: Früherkennungssprechstunde Psychose

Mainz
Johannes Gutenberg-Universität Mainz: Ambulanz für Psychose-Früherkennung Rheinhessen!

München
Klinikum der Universität München: PRONIA Früherkennung

Rheinhessen
Rheinhessen-Fachklinik Alzey: Psychose-Früherkennungsambulanz Rheinhessen
(angegliedert an die Uniklinik Mainz)

• Lambert M, Schöttle D, Sengutta M, Lüdecke D, Nawara AL, Galling B, Handwerk U, Rothländer W, Falk AL, Rietschel L, Gagern C, Sarikaya G, Wittmann L, Ruppelt F, Daubmann A, Lange B, Naber D, Schulte-Markwort M, Unger HP, Ott S, Romer G, Krüger H, Gallinat J, Wegscheider K, Bock T, Karow A. [Early Detection and Integrated Care in Adolescents and Young Adults with Severe Psychotic Illnesses]. Psychiatr Prax. 2015 Jul;42 Suppl 1:S49-53. doi: 10.1055/s-0034-1387652. Epub 2015 Jul 2. German. PubMed PMID: 26135281.
• Pfennig A, Klosterkötter J. [Check-ups and screening for young people: what is reasonable with respect to psychiatric disorders?]. Nervenarzt. 2014 Dec;85(12):1544-50. doi: 10.1007/s00115-013-3979-1. German. PubMed PMID: 25367230.
• Leopold K, Nikolaides A, Bauer M, Bechdolf A, Correll CU, Jessen F, Juckel G, Karow A, Lambert M, Klosterkötter J, Ruhrmann S, Pfeiffer S, Pfennig A. [Services for the early recognition of psychoses and bipolar disorders in Germany: inventory survey study]. Nervenarzt. 2015 Mar;86(3):352-8. doi: 10.1007/s00115-014-4119-2. German. PubMed PMID: 25022895.
• Karow A, Bock T, Naber D, Löwe B, Schulte-Markwort M, Schäfer I, Gumz A, Degkwitz P, Schulte B, König HH, Konnopka A, Bauer M, Bechdolf A, Correll C, Juckel G, Klosterkötter J, Leopold K, Pfennig A, Lambert M. [Mental health of children, adolescents and young adults--part 2: burden of illness, deficits of the German health care system and efficacy and effectiveness of early intervention services]. Fortschr Neurol Psychiatr. 2013 Nov;81(11):628-38. doi: 10.1055/s-0033-1355840. Epub 2013 Nov 5. Review. German. PubMed PMID: 24194056.
• Lambert M, Bock T, Naber D, Löwe B, Schulte-Markwort M, Schäfer I, Gumz A, Degkwitz P, Schulte B, König HH, Konnopka A, Bauer M, Bechdolf A, Correll C, Juckel G, Klosterkötter J, Leopold K, Pfennig A, Karow A. [Mental health of children, adolescents and young adults--part 1: prevalence, illness persistence, adversities, service use, treatment delay and consequences]. Fortschr Neurol Psychiatr. 2013 Nov;81(11):614-27. doi: 10.1055/s-0033-1355843. Epub 2013 Nov 5. Review. German. Erratum in: Fortschr Neurol Psychiatr. 2013 Nov;81(11):e1-2. PubMed PMID: 24194055.
• Leopold K, Pfeiffer S, Correll CU, Bauer M, Pfennig A. [Early recognition centers for mental disorders - a complementary supply in the german health system]. Psychiatr Prax. 2013 Jul;40(5):264-70. doi: 10.1055/s-0032-1332972. Epub 2013 Mar 18. German. PubMed PMID: 23508775.

EPA Guidance papers

• Schultze-Lutter F, Michel C, Schmidt SJ, Schimmelmann BG, Maric NP, Salokangas RK, Riecher-Rössler A, van der Gaag M, Nordentoft M, Raballo A, Meneghelli A, Marshall M, Morrison A, Ruhrmann S, Klosterkötter J. EPA guidance on the early detection of clinical high risk states of psychoses. Eur Psychiatry. 2015 Mar;30(3):405-16. doi: 10.1016/j.eurpsy.2015.01.010. Epub 2015 Feb 27. PubMed PMID: 25735810.
• Schmidt SJ, Schultze-Lutter F, Schimmelmann BG, Maric NP, Salokangas RK, Riecher-Rössler A, van der Gaag M, Meneghelli A, Nordentoft M, Marshall M, Morrison A, Raballo A, Klosterkötter J, Ruhrmann S. EPA guidance on the early intervention in clinical high risk states of psychoses. Eur Psychiatry. 2015 Mar;30(3):388-404. doi: 10.1016/j.eurpsy.2015.01.013. Epub 2015 Mar 3. PubMed PMID: 25749390

Weitere

• Fusar-Poli P, Schultze-Lutter F, Cappucciati M, Rutigliano G, Bonoldi I, Stahl D, Borgwardt S, Riecher-Rössler A, Addington J, Perkins DO, Woods SW, McGlashan T, Lee J, Klosterkötter J, Yung AR, McGuire P. The Dark Side of the Moon: Meta-analytical Impact of Recruitment Strategies on Risk Enrichment in theClinical High Risk State for Psychosis. Schizophr Bull. 2015 Nov 20. pii: sbv162. [Epub ahead of print] PubMed PMID: 26591006.
• Fusar-Poli P, Cappucciati M, Rutigliano G, Schultze-Lutter F, Bonoldi I, Borgwardt S, Riecher-Rössler A, Addington J, Perkins D, Woods SW, McGlashan TH, Lee J, Klosterkötter J, Yung AR, McGuire P. At risk or not at risk? A meta-analysis of the prognostic accuracy of psychometric interviews for psychosis prediction. World Psychiatry. 2015 Oct;14(3):322-32. doi: 10.1002/wps.20250. PubMed PMID: 26407788; PubMed Central PMCID: PMC4592655.
• Schultze-Lutter F, Rahman J, Ruhrmann S, Michel C, Schimmelmann BG, Maier W, Klosterkötter J. Duration of unspecific prodromal and clinical high risk states, and early help-seeking in first-admission psychosis patients. Soc Psychiatry Psychiatr Epidemiol. 2015 Dec;50(12):1831-41. doi: 10.1007/s00127-015-1093-3. Epub 2015 Jul 9. PubMed PMID: 26155901.
• Klosterkötter J. The usefulness for indicated prevention of severe mental disorders should play a central part in the further development of CBT. World Psychiatry. 2014 Oct;13(3):259-60. doi: 10.1002/wps.20163. PubMed PMID: 25273296; PubMed Central PMCID: PMC4219064.
• Ruhrmann S, Schultze-Lutter F, Schmidt SJ, Kaiser N, Klosterkötter J. Prediction and prevention of psychosis: current progress and future tasks. Eur Arch Psychiatry Clin Neurosci. 2014 Nov;264 Suppl 1:S9-16. doi: 10.1007/s00406-014-0541-5. Epub 2014 Sep 26. PubMed PMID: 25256263.
• Klosterkötter J. [Prediction of psychoses]. Nervenarzt. 2014 Oct;85(10):1238-48. doi: 10.1007/s00115-014-4046-2. Review. German. PubMed PMID: 25148868.
• Bechdolf A. [Risk states for psychosis as a distinct diagnostic category -pro]. Psychiatr Prax. 2014 Apr;41(3):124-5. doi: 10.1055/s-0034-1369836. Epub 2014 Apr 1. German. PubMed PMID: 24691788.

Studienprotokolle laufender Studien

• PREVENT: Bechdolf A, Müller H, Stützer H, Wagner M, Maier W, Lautenschlager M, Heinz A, de Millas W, Janssen B, Gaebel W, Michel TM, Schneider F, Lambert M, Naber D, Brüne M, Krüger-Özgürdal S, Wobrock T, Riedel M, Klosterkötter J; PREVENT study group. Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosis. Schizophr Bull. 2011 Sep;37 Suppl 2:S111-21. doi: 10.1093/schbul/sbr083. PubMed PMID: 21860040; PubMed Central PMCID: PMC3160113.

• Bechdolf A, Ratheesh A, Cotton SM, Nelson B, Chanen AM, Betts J, Bingmann T, Yung AR, Berk M, McGorry PD. The predictive validity of bipolar at-risk (prodromal) criteria in help-seeking adolescents and young adults: a prospective study. Bipolar Disord. 2014 Aug;16(5):493-504. doi: 10.1111/bdi.12205. Epub 2014 May 5. PubMed PMID: 24797824.
• Pfennig A, Ritter PS, Höfler M, Lieb R, Bauer M, Wittchen HU, Beesdo-Baum K. Symptom characteristics of depressive episodes prior to the onset of mania or hypomania. Acta Psychiatr Scand. 2016 Mar;133(3):196-204. doi: 10.1111/acps.12469. Epub 2015 Aug 7. PubMed PMID: 26252885.
• Ritter PS, Höfler M, Wittchen HU, Lieb R, Bauer M, Pfennig A, Beesdo-Baum K. Disturbed sleep as risk factor for the subsequent onset of bipolar disorder—Data from a 10-year prospective-longitudinal study among adolescents and young adults. J Psychiatr Res. 2015 Sep;68:76-82. doi: 10.1016/j.jpsychires.2015.06.005. Epub 2015 Jun 16. PubMed PMID: 26228404.
• Bauer M, Glenn T, Alda M, Andreassen OA, Angelopoulos E, Ardau R, Baethge C, Bauer R, Baune BT, Bellivier F, Belmaker RH, Berk M, Bjella TD, Bossini L, Bersudsky Y, Wo Cheung EY, Conell J, Del Zompo M, Dodd S, Etain B, Fagiolini A, Frye MA, Fountoulakis KN, Garneau-Fournier J, Gonzalez-Pinto A, Gottlieb JF, Harima H, Hassel S, Henry C, Iacovides A, Isometsä ET, Kapczinski F, Kliwicki S, König B, Krogh R, Kunz M, Lafer B, Larsen ER, Lewitzka U, Lopez-Jaramillo C, MacQueen G, Manchia M, Marsh W, Martinez-Cengotitabengoa M, Melle I, Monteith S, Morken G, Munoz R, Nery FG, O'Donovan C, Osher Y, Pfennig A, Quiroz D, Ramesar R, Rasgon N, Reif A, Ritter P, Rybakowski JK, Sagduyu K, Miranda-Scippa Â, SeverusE, Simhandl C, Stein DJ, Strejilevich S, Sulaiman AH, Suominen K, Tagata H, Tatebayashi Y, Torrent C, Vieta E, Viswanath B, Wanchoo MJ, Zetin M, Whybrow PC. Influence of light exposure during early life on the age of onset of bipolar disorder. J Psychiatr Res. 2015 May;64:1-8. doi: 10.1016/j.jpsychires.2015.03.013. Epub 2015 Mar 27. Review. PubMed PMID: 25862378.
• Zeschel E, Bingmann T, Bechdolf A, Krüger-Oezguerdal S, Correll CU, Leopold K, Pfennig A, Bauer M, Juckel G. Temperament and prodromal symptoms prior to first manic/hypomanic episodes: results from a pilot study. J Affect Disord. 2015 Mar 1;173:39-44. doi: 10.1016/j.jad.2014.10.031. Epub 2014 Oct 22. PubMed PMID: 25462394.
• Leopold K, Ratzer S, Correll CU, Rottmann-Wolf M, Pfeiffer S, Ritter P, Bauer M, Pfennig A. Characteristics, symptomatology and naturalistic treatment in individuals at-risk for bipolar disorders: baseline results in the first 180 help-seeking individuals assessed at the Dresden high-risk project. J Affect Disord. 2014 Jan;152-154:427-33. doi: 10.1016/j.jad.2013.10.009. Epub 2013 Oct 12. PubMed PMID: 24206928.
• Leopold K, Pfennig A, Severus E, Bauer M. [Prevention of bipolar disorders]. Nervenarzt. 2013 Nov;84(11):1310-5. doi: 10.1007/s00115-013-3834-4. German. PubMed PMID: 24113853.
• Pfennig A, Correll CU, Marx C, Rottmann-Wolf M, Meyer TD, Bauer M, Leopold K. Psychotherapeutic interventions in individuals at risk of developing bipolar disorder: a systematic review. Early Interv Psychiatry. 2014 Feb;8(1):3-11. doi: 10.1111/eip.12082. Epub 2013 Aug 22. Review. PubMed PMID: 23968367.
• Zeschel E, Correll CU, Haussleiter IS, Krüger-Özgürdal S, Leopold K, Pfennig A, Bechdolf A, Bauer M, Juckel G. The bipolar disorder prodrome revisited: Is there a symptomatic pattern? J Affect Disord. 2013 Nov;151(2):551-60. doi: 10.1016/j.jad.2013.06.043. Epub 2013 Aug 8. PubMed PMID: 23932736.

Studienprotokolle laufender Studien

EarlyCBT: Pfennig A, Leopold K, Bechdolf A, Correll CU, Holtmann M, Lambert M, Marx C, Meyer TD, Pfeiffer S, Reif A, Rottmann-Wolf M, Schmitt NM, Stamm T, Juckel G, Bauer M. Early specific cognitive-behavioural psychotherapy in subjects at high risk for bipolar disorders: study protocol for a randomised controlled trial. Trials. 2014 May 8;15:161. doi: 10.1186/1745-6215-15-161. PubMed PMID: 24886581; PubMed Central PMCID: PMC4020379.

• Zäske H, Degner D, Jockers-Scherübl M, Klingberg S, Klosterkötter J, Maier W, Möller HJ, Sauer H, Schmitt A, Gaebel W. [Experiences of stigma and discrimination in patients with first-episode schizophrenia]. Nervenarzt. 2016 Jan;87(1):82-7. doi: 10.1007/s00115-015-4340-7. German. PubMed PMID: 26099499.
• Müller H, Laier S, Bechdolf A. Evidence-based psychotherapy for the prevention and treatment of first-episode psychosis. Eur Arch Psychiatry Clin Neurosci. 2014 Nov;264 Suppl 1:S17-25. doi: 10.1007/s00406-014-0538-0. Epub 2014 Sep 27. Review.  PubMed PMID: 25261211.

• Wolfsgruber S, Jessen F, Koppara A, Kleineidam L, Schmidtke K, Frölich L, Kurz A, Schulz S, Hampel H, Heuser I, Peters O, Reischies FM, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Pantel J, Rienhoff O, Rüther E, Henn F, Wiltfang J, Maier W, Kornhuber J, Wagner M. Subjective cognitive decline is related to CSF biomarkers of AD in patients with MCI. Neurology. 2015 Mar 24;84(12):1261-8. doi: 10.1212/WNL.0000000000001399. Epub 2015 Feb 25. PubMed PMID: 25716354.
• Ramirez A, Wolfsgruber S, Lange C, Kaduszkiewicz H, Weyerer S, Werle J, Pentzek M, Fuchs A, Riedel-Heller SG, Luck T, Mösch E, Bickel H, Wiese B, Prokein J, König HH, Brettschneider C, Breteler MM, Maier W, Jessen F, Scherer M; AgeCoDe Study Group. Elevated HbA1c is associated with increased risk of incident dementia in primary care patients. J Alzheimers Dis. 2015;44(4):1203-12. doi: 10.3233/JAD-141521. PubMed PMID: 25524954.
• Jessen F, Dodel R. [Prediction of Alzheimer's dementia]. Nervenarzt. 2014 Oct;85(10):1233-7. doi: 10.1007/s00115-014-4064-0. German. PubMed PMID: 25231823.
• Luck T, Luppa M, Matschinger H, Jessen F, Angermeyer MC, Riedel-Heller SG. Incident subjective memory complaints and the risk of subsequent dementia. Acta Psychiatr Scand. 2015 Apr;131(4):290-6. doi: 10.1111/acps.12328. Epub 2014 Sep 9. PubMed PMID: 25201166.
• Wolfsgruber S, Wagner M, Schmidtke K, Frölich L, Kurz A, Schulz S, Hampel H, Heuser I, Peters O, Reischies FM, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Pantel J, Rienhoff O, Rüther E, Henn F, Wiltfang J, Maier W, Kornhuber J, Jessen F. Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment. PLoS One. 2014 Jul 14;9(7):e100812. doi: 10.1371/journal.pone.0100812. eCollection 2014. PubMed PMID: 25019225; PubMed Central PMCID: PMC4096405.
• Kaduszkiewicz H, Eisele M, Wiese B, Prokein J, Luppa M, Luck T, Jessen F, Bickel H, Mösch E, Pentzek M, Fuchs A, Eifflaender-Gorfer S, Weyerer S, König HH, Brettschneider C, van den Bussche H, Maier W, Scherer M, Riedel-Heller SG; Study on Aging, Cognition, and Dementia in Primary Care Patients (AgeCoDe) Study Group. Prognosis of mild cognitive impairment in general practice: results of the German AgeCoDe study. Ann Fam Med. 2014 Mar-Apr;12(2):158-65. doi: 10.1370/afm.1596. PubMed PMID: 24615312; PubMed Central PMCID: PMC3948763.